Title |
Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells
|
---|---|
Published in |
BMC Complementary Medicine and Therapies, August 2013
|
DOI | 10.1186/1472-6882-13-212 |
Pubmed ID | |
Authors |
Liron Berkovich, Gideon Earon, Ilan Ron, Adam Rimmon, Akiva Vexler, Shahar Lev-Ari |
Abstract |
Fewer than 6% patients with adenocarcinoma of the pancreas live up to five years after diagnosis. Chemotherapy is currently the standard treatment, however, these tumors often develop drug resistance over time. Agents for increasing the cytotoxic effects of chemotherapy or reducing the cancer cells' chemo-resistance to the drugs are required to improve treatment outcome. Nuclear factor kappa B (NF-kB), a pro-inflammatory transcription factor, reportedly plays a significant role in the resistance of pancreatic cancer cells to apoptosis-based chemotherapy. This study investigated the effect of aqueous Moringa Oleifera leaf extract on cultured human pancreatic cancer cells - Panc-1, p34, and COLO 357, and whether it can potentiates the effect of cisplatin chemotherapy on these cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 13 | 50% |
United Kingdom | 2 | 8% |
Netherlands | 1 | 4% |
Canada | 1 | 4% |
Malaysia | 1 | 4% |
Spain | 1 | 4% |
South Africa | 1 | 4% |
Costa Rica | 1 | 4% |
Unknown | 5 | 19% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 22 | 85% |
Practitioners (doctors, other healthcare professionals) | 3 | 12% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
India | 1 | <1% |
China | 1 | <1% |
Unknown | 384 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 58 | 15% |
Student > Master | 53 | 14% |
Student > Ph. D. Student | 45 | 12% |
Student > Doctoral Student | 22 | 6% |
Researcher | 18 | 5% |
Other | 54 | 14% |
Unknown | 137 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 65 | 17% |
Biochemistry, Genetics and Molecular Biology | 43 | 11% |
Medicine and Dentistry | 34 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 30 | 8% |
Chemistry | 18 | 5% |
Other | 49 | 13% |
Unknown | 148 | 38% |