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Immunomodulatory constituents of human breast milk and immunity from bronchiolitis

Overview of attention for article published in Italian Journal of Pediatrics, January 2017
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Title
Immunomodulatory constituents of human breast milk and immunity from bronchiolitis
Published in
Italian Journal of Pediatrics, January 2017
DOI 10.1186/s13052-017-0326-3
Pubmed ID
Authors

Chunyu Li, Yanbo Liu, Yanfang Jiang, Naijun Xu, Jie Lei

Abstract

The mother's immune status can be achieved by genetic and breastfeeding impact descendants of the immune system. The study aimed to determine whether a mother's immune status and breastfeeding practices were related to development of bronchiolitis in her infant. The frequency of T, B and natural kill (NK) cells in patients' blood and their mothers' breast milk was determined using flow cytometry. The concentrations of serum and breast milk IgG and IgD in individual patients and healthy control were determined by enzyme-linked immunosorbent assay (ELISA). The relationships between immunocytes, immunoglobulin and respiratory score (RS) were analyzed by Spearman's rank correlation test. The mothers of bronchiolitis patients had lower IgG concentrations in their breast milk when compared to the mothers of healthy children. There was no significant difference in the frequency of T cells, B cells, and NK cells in samples of breast milk. However, significant decreases of CD3+, CD8+ T cells, as well as significant increases of CD4+ T cells and CD19+ B cells were found in the serum of bronchiolitis infants. There were positive correlation relationships between RS and CD3+, CD4+ T cells, IgG and IgD concentrations. Our data suggested that the mothers of bronchiolitis patients had lower IgG concentration in their breast milk. The breast milk IgG might be absorbed by the breastfeeding infants, which could play important role in resistance of bronchiolitis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 26%
Student > Master 5 11%
Student > Doctoral Student 5 11%
Student > Ph. D. Student 4 9%
Researcher 3 6%
Other 7 15%
Unknown 11 23%
Readers by discipline Count As %
Medicine and Dentistry 13 28%
Nursing and Health Professions 13 28%
Agricultural and Biological Sciences 3 6%
Immunology and Microbiology 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 3 6%
Unknown 11 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2017.
All research outputs
#6,644,663
of 9,153,782 outputs
Outputs from Italian Journal of Pediatrics
#196
of 378 outputs
Outputs of similar age
#170,915
of 253,475 outputs
Outputs of similar age from Italian Journal of Pediatrics
#4
of 8 outputs
Altmetric has tracked 9,153,782 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 378 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,475 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.