Title |
Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status
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Published in |
Arquivos de Neuro-Psiquiatria, April 2015
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DOI | 10.1590/0004-282x20150003 |
Pubmed ID | |
Authors |
Matheus Fernandes de Oliveira, Jose Marcus Rotta, Ricardo Vieira Botelho |
Abstract |
Spine is the most common site for skeletal metastasis in patients with malignancy. Vertebral involvement quantification, neurological status, general health status and primary tumor histology are factors to set surgical planning and therapeutic targets. We evaluated the impact of general clinical and neurological status, histologic type and surgery in survival. The study sample consisted of consecutive patients admitted from July 2010 to January 2013 for treatment. Sixty eight patients were evaluated. 23 were female and 45 were male. Main primary neoplasic sites were: breast, prostate, lung/pleura and linfoproliferative. Thirty three out of 68 received surgical treatment, 2 received percutaneous biopsy and 33 had nonsurgical treatment. Survival : Log Rank curves revealed no statistical significant difference according to histological type, surgical approach and Frankel Score. Karnofsky Score was statistically different. Histological type and clinical status were statistically associated with life expectancy in vertebral metastatic disease. |
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Geographical breakdown
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Netherlands | 1 | 2% |
Italy | 1 | 2% |
Unknown | 48 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 16% |
Student > Master | 8 | 16% |
Student > Bachelor | 6 | 12% |
Other | 5 | 10% |
Professor | 2 | 4% |
Other | 7 | 14% |
Unknown | 14 | 28% |
Readers by discipline | Count | As % |
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Unspecified | 2 | 4% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 0 | 0% |
Unknown | 18 | 36% |