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Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly

Overview of attention for article published in Nature Chemistry, September 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
10 news outlets
blogs
3 blogs
twitter
11 tweeters
patent
2 patents
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
170 Dimensions

Readers on

mendeley
181 Mendeley
citeulike
2 CiteULike
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Title
Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly
Published in
Nature Chemistry, September 2013
DOI 10.1038/nchem.1745
Pubmed ID
Authors

Thomas G. W. Edwardson, Karina M. M. Carneiro, Christopher K. McLaughlin, Christopher J. Serpell, Hanadi F. Sleiman

Abstract

Nature uses a combination of non-covalent interactions to create a hierarchy of complex systems from simple building blocks. One example is the selective association of the hydrophobic side chains that are a strong determinant of protein organization. Here, we report a parallel mode of assembly in DNA nanotechnology. Dendritic alkyl-DNA conjugates are hybridized to the edges of a DNA cube. When four amphiphiles are on one face, the hydrophobic residues of two neighbouring cubes engage in an intermolecular 'handshake', resulting in a dimer. When there are eight amphiphiles (four on the top and bottom cube faces, respectively), they engage in an intramolecular 'handshake' inside the cube. This forms the first example of a monodisperse micelle within a DNA nanostructure that encapsulates small molecules and releases them by DNA recognition. Creating a three-dimensional pattern of hydrophobic patches, like side chains in proteins, can result in specific, directed association of hydrophobic domains with orthogonal interactions to DNA base-pairing.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 2%
Netherlands 1 <1%
France 1 <1%
India 1 <1%
Italy 1 <1%
Canada 1 <1%
Mexico 1 <1%
Belgium 1 <1%
Korea, Republic of 1 <1%
Other 1 <1%
Unknown 168 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 52 29%
Researcher 34 19%
Student > Master 25 14%
Student > Bachelor 18 10%
Student > Doctoral Student 11 6%
Other 26 14%
Unknown 15 8%
Readers by discipline Count As %
Chemistry 80 44%
Biochemistry, Genetics and Molecular Biology 25 14%
Agricultural and Biological Sciences 24 13%
Materials Science 9 5%
Engineering 8 4%
Other 17 9%
Unknown 18 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 108. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2021.
All research outputs
#290,183
of 21,347,686 outputs
Outputs from Nature Chemistry
#173
of 2,851 outputs
Outputs of similar age
#2,298
of 179,671 outputs
Outputs of similar age from Nature Chemistry
#3
of 49 outputs
Altmetric has tracked 21,347,686 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,851 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,671 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.