Title |
Unravelling the molecular complexity of GPCR‐mediated EGFR transactivation using functional genomics approaches
|
---|---|
Published in |
FEBS Journal, September 2013
|
DOI | 10.1111/febs.12509 |
Pubmed ID | |
Authors |
Amee J. George, Ross D. Hannan, Walter G. Thomas |
Abstract |
To influence physiology and pathophysiology, G protein-coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains incomplete. In this review, we describe the current view of GPCR-EGFR transactivation, identifying the established models of receptor cross-talk. We consider the limitations in our current knowledge, and propose that recent advances in molecular and cell biology technology, including functional genomics approaches, will allow a renewed focus of efforts to understand the mechanism underlying EGFR transactivation. Using an unbiased approach for identification of the molecules required for GPCR-mediated EGFR transactivation will provide a contemporary and more complete representation from which to extrapolate therapeutic control in diseases from cardiovascular remodelling to cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 2 | 3% |
United States | 1 | 1% |
Germany | 1 | 1% |
Unknown | 72 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 26% |
Researcher | 14 | 18% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 7 | 9% |
Professor | 6 | 8% |
Other | 11 | 14% |
Unknown | 10 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 32% |
Biochemistry, Genetics and Molecular Biology | 19 | 25% |
Medicine and Dentistry | 11 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Chemistry | 2 | 3% |
Other | 4 | 5% |
Unknown | 11 | 14% |