Title |
Liposomal extended-release bupivacaine for postsurgical analgesia
|
---|---|
Published in |
Patient preference and adherence, September 2013
|
DOI | 10.2147/ppa.s32175 |
Pubmed ID | |
Authors |
Zongbing You, Lambrechts, Michael O'Brien, Savoie |
Abstract |
When physicians consider which analgesia to use postsurgery, the primary goal is to relieve pain with minimal adverse side effects. Bupivacaine, a commonly used analgesic, has been formulated into an aqueous suspension of multivesicular liposomes that provide long-lasting analgesia for up to 72 hours, while avoiding the adverse side effects of opioids. The increased efficacy of liposomal extended-release bupivacaine, compared to bupivacaine hydrochloride, has promoted its usage in a variety of surgeries including hemorrhoidectomy, bunionectomy, inguinal hernia repair, total knee arthroplasty, and augmentation mammoplasty. However, like other bupivacaine formulations, the liposomal extended-release bupivacaine does have some side effects. In this brief review, we provide an update of the current knowledge in the use of bupivacaine for postsurgical analgesia. |
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