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Alteration of the microRNA network during the progression of Alzheimer's disease

Overview of attention for article published in EMBO Molecular Medicine, September 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

twitter
22 tweeters
patent
6 patents

Citations

dimensions_citation
178 Dimensions

Readers on

mendeley
193 Mendeley
citeulike
1 CiteULike
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Title
Alteration of the microRNA network during the progression of Alzheimer's disease
Published in
EMBO Molecular Medicine, September 2013
DOI 10.1002/emmm.201201974
Pubmed ID
Authors

Pierre Lau, Koen Bossers, Rekin's Janky, Evgenia Salta, Carlo Sala Frigerio, Shahar Barbash, Roy Rothman, Annerieke S. R. Sierksma, Amantha Thathiah, David Greenberg, Aikaterini S. Papadopoulou, Tilmann Achsel, Torik Ayoubi, Hermona Soreq, Joost Verhaagen, Dick F. Swaab, Stein Aerts, Bart De Strooper

Abstract

An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late-onset AD (LOAD) patients and 23 controls, showing deregulation of 35 miRNAs. Profiling of miRNAs in the prefrontal cortex of a second independent cohort of 49 patients grouped by Braak stages revealed 41 deregulated miRNAs. We focused on miR-132-3p which is strongly altered in both brain areas. Downregulation of this miRNA occurs already at Braak stages III and IV, before loss of neuron-specific miRNAs. Next-generation sequencing confirmed a strong decrease of miR-132-3p and of three family-related miRNAs encoded by the same miRNA cluster on chromosome 17. Deregulation of miR-132-3p in AD brain appears to occur mainly in neurons displaying Tau hyper-phosphorylation. We provide evidence that miR-132-3p may contribute to disease progression through aberrant regulation of mRNA targets in the Tau network. The transcription factor (TF) FOXO1a appears to be a key target of miR-132-3p in this pathway.

Twitter Demographics

The data shown below were collected from the profiles of 22 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Australia 1 <1%
Chile 1 <1%
Italy 1 <1%
Brazil 1 <1%
Belgium 1 <1%
Korea, Republic of 1 <1%
Czech Republic 1 <1%
Canada 1 <1%
Other 6 3%
Unknown 178 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 48 25%
Student > Ph. D. Student 46 24%
Student > Master 27 14%
Student > Bachelor 24 12%
Student > Postgraduate 13 7%
Other 35 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 83 43%
Neuroscience 28 15%
Biochemistry, Genetics and Molecular Biology 26 13%
Medicine and Dentistry 25 13%
Unspecified 14 7%
Other 17 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2018.
All research outputs
#526,592
of 11,954,851 outputs
Outputs from EMBO Molecular Medicine
#125
of 830 outputs
Outputs of similar age
#7,671
of 146,083 outputs
Outputs of similar age from EMBO Molecular Medicine
#6
of 13 outputs
Altmetric has tracked 11,954,851 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 830 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.