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Inflammation Induced by MMP-9 Enhances Tumor Regression of Experimental Breast Cancer

Overview of attention for article published in The Journal of Immunology, January 2013
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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2 tweeters

Citations

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38 Dimensions

Readers on

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44 Mendeley
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Title
Inflammation Induced by MMP-9 Enhances Tumor Regression of Experimental Breast Cancer
Published in
The Journal of Immunology, January 2013
DOI 10.4049/jimmunol.1202610
Pubmed ID
Authors

Karin Söderlund Leifler, Susanne Svensson, Annelie Abrahamsson, Christina Bendrik, Jennifer Robertson, Jack Gauldie, Anna-Karin Olsson, Charlotta Dabrosin

Abstract

Matrix metalloproteinases (MMPs) have been suggested as therapeutic targets in cancer treatment, but broad-spectrum MMP inhibitors have failed in clinical trials. Recent data suggest that several MMPs including MMP-9 exert both pro- and antitumorigenic properties. This is also the case of the natural inhibitors of MMPs, tissue inhibitor of metalloproteinases (TIMPs). The inhibitor of MMP-9 is TIMP-1, and high levels of this enzyme have been associated with decreased survival in breast cancer. Inflammation is one hallmark of cancer progression, and MMPs/TIMPs may be involved in the local immune regulation. We investigated the role of MMP-9/TIMP-1 in regulating innate antitumor immunity in breast cancer. Breast cancers were established in nude mice and treated with intratumoral injections of adenoviruses carrying the human TIMP-1 or MMP-9 gene (AdMMP-9). In vivo microdialysis for sampling of cancer cell-derived (human) and stroma-derived (murine) proteins, immunostainings, as well as cell cultures were performed. We report a dose-dependent decrease of tumor growth and angiogenesis after AdMMP-9 treatment. In addition to increased generation of endostatin, AdMMP-9 promoted an antitumor immune response by inducing massive neutrophil infiltration. Neutrophil depletion prior to gene transfer abolished the therapeutic effects of AdMMP-9. Additionally, AdMMP-9 activated tumor-infiltrating macrophages into a tumor-inhibiting phenotype both in vivo and in vitro. AdMMP-9 also inhibited tumor growth in immune-competent mice bearing breast cancers. Adenoviruses carrying the human TIMP-1 gene had no effect on tumor growth or the immune response. Our novel data identify MMP-9 as a potent player in modulating the innate immune response into antitumor activities.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 2%
China 1 2%
Iran, Islamic Republic of 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 39%
Student > Master 8 18%
Researcher 7 16%
Student > Bachelor 3 7%
Student > Doctoral Student 3 7%
Other 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 50%
Medicine and Dentistry 13 30%
Biochemistry, Genetics and Molecular Biology 4 9%
Immunology and Microbiology 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2013.
All research outputs
#2,736,925
of 6,229,091 outputs
Outputs from The Journal of Immunology
#3,089
of 6,568 outputs
Outputs of similar age
#48,149
of 105,162 outputs
Outputs of similar age from The Journal of Immunology
#21
of 67 outputs
Altmetric has tracked 6,229,091 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 6,568 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,162 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.