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Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill

Overview of attention for article published in PLoS Genetics, September 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#27 of 6,296)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
27 news outlets
blogs
6 blogs
twitter
82 tweeters
facebook
5 Facebook pages
wikipedia
3 Wikipedia pages
googleplus
5 Google+ users
video
2 video uploaders

Citations

dimensions_citation
65 Dimensions

Readers on

mendeley
149 Mendeley
citeulike
1 CiteULike
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Title
Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill
Published in
PLoS Genetics, September 2013
DOI 10.1371/journal.pgen.1003751
Pubmed ID
Authors

William M. Brandler, Andrew P. Morris, David M. Evans, Thomas S. Scerri, John P. Kemp, Nicholas J. Timpson, Beate St Pourcain, George Davey Smith, Susan M. Ring, John Stein, Anthony P. Monaco, Joel B. Talcott, Simon E. Fisher, Caleb Webber, Silvia Paracchini

Abstract

Humans display structural and functional asymmetries in brain organization, strikingly with respect to language and handedness. The molecular basis of these asymmetries is unknown. We report a genome-wide association study meta-analysis for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)] (n = 728). The most strongly associated variant, rs7182874 (P = 8.68 × 10(-9)), is located in PCSK6, further supporting an association we previously reported. We also confirmed the specificity of this association in individuals with RD; the same locus was not associated with relative hand skill in a general population cohort (n = 2,666). As PCSK6 is known to regulate NODAL in the development of left/right (LR) asymmetry in mice, we developed a novel approach to GWAS pathway analysis, using gene-set enrichment to test for an over-representation of highly associated variants within the orthologs of genes whose disruption in mice yields LR asymmetry phenotypes. Four out of 15 LR asymmetry phenotypes showed an over-representation (FDR ≤ 5%). We replicated three of these phenotypes; situs inversus, heterotaxia, and double outlet right ventricle, in the general population cohort (FDR ≤ 5%). Our findings lead us to propose that handedness is a polygenic trait controlled in part by the molecular mechanisms that establish LR body asymmetry early in development.

Twitter Demographics

The data shown below were collected from the profiles of 82 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
United Kingdom 3 2%
Netherlands 2 1%
Slovenia 1 <1%
Finland 1 <1%
China 1 <1%
Austria 1 <1%
Serbia 1 <1%
Canada 1 <1%
Other 6 4%
Unknown 128 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 22%
Student > Master 24 16%
Student > Bachelor 23 15%
Researcher 21 14%
Student > Doctoral Student 13 9%
Other 35 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 51 34%
Medicine and Dentistry 20 13%
Biochemistry, Genetics and Molecular Biology 18 12%
Psychology 13 9%
Unspecified 11 7%
Other 36 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 303. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2019.
All research outputs
#33,309
of 12,380,104 outputs
Outputs from PLoS Genetics
#27
of 6,296 outputs
Outputs of similar age
#419
of 155,184 outputs
Outputs of similar age from PLoS Genetics
#1
of 204 outputs
Altmetric has tracked 12,380,104 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,296 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,184 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.