Title |
Regulatory T cells in nonlymphoid tissues
|
---|---|
Published in |
Nature Immunology, September 2013
|
DOI | 10.1038/ni.2683 |
Pubmed ID | |
Authors |
Dalia Burzyn, Christophe Benoist, Diane Mathis |
Abstract |
Both Foxp3(+)CD4(+) regulatory T cells (Treg cells) and local immune responses in nonlymphoid tissues have long been recognized as important elements of a well-orchestrated immune system, but only recently have these two fields of study begun to intersect. There is growing evidence that Treg cells are present in various nonlymphoid tissues in health and disease, that they have a unique phenotype and that their functions go beyond the classical modulation of immune responses. Thus, tissue Treg cells might add yet another level to classification of the Treg cell compartment into functional and/or phenotypic subtypes. In this Review, we summarize recent findings in this new field, discussing knowns and unknowns about the origin, phenotype, function and memory of nonlymphoid tissue-resident Treg cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | <1% |
Japan | 3 | <1% |
Brazil | 3 | <1% |
United Kingdom | 2 | <1% |
India | 1 | <1% |
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Belgium | 1 | <1% |
France | 1 | <1% |
Other | 2 | <1% |
Unknown | 455 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 115 | 24% |
Researcher | 100 | 21% |
Student > Master | 48 | 10% |
Student > Bachelor | 32 | 7% |
Student > Doctoral Student | 30 | 6% |
Other | 80 | 17% |
Unknown | 69 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 138 | 29% |
Immunology and Microbiology | 99 | 21% |
Medicine and Dentistry | 73 | 15% |
Biochemistry, Genetics and Molecular Biology | 57 | 12% |
Neuroscience | 7 | 1% |
Other | 22 | 5% |
Unknown | 78 | 16% |