Title |
Molecular epidemiological study of clinical Acinetobacter baumannii isolates: phenotype switching of antibiotic resistance
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Published in |
Annals of Clinical Microbiology and Antimicrobials, August 2013
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DOI | 10.1186/1476-0711-12-21 |
Pubmed ID | |
Authors |
Chang-Hua Chen, Chieh-Chen Huang |
Abstract |
The presence of clinical Acinetobacter baumannii (A. baumannii) isolates with differing antibiotic resistance phenotypes in the same patient causes difficulties and confusion in treatment. This phenomenon may be caused by reasons such as cross-infection from neighboring patients that switches to different A. baumannii strain, natural mutation of A. baumannii, inducing of different antibiotic resistance genes expression or acquisition of genes conferring resistance from another source. To elucidate this question, clinical A. baumannii strains, isolated from the same individual patients, showed antibiotic resistance phenotypes switching during the same hospitalization period, were attentively collected for further analysis. Molecular approaches for phylogenetic analysis, including pulsed field gel electrophoresis, multilocus sequence typing, and short tandem repeat analysis, were employed for the chronological studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | 3% |
Unknown | 33 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 6 | 18% |
Student > Ph. D. Student | 5 | 15% |
Student > Bachelor | 5 | 15% |
Student > Master | 4 | 12% |
Student > Doctoral Student | 2 | 6% |
Other | 6 | 18% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 24% |
Medicine and Dentistry | 8 | 24% |
Immunology and Microbiology | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Computer Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 8 | 24% |