Title |
Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data
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Published in |
BMC Bioinformatics, September 2013
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DOI | 10.1186/1471-2105-14-280 |
Pubmed ID | |
Authors |
Marcin Kruczyk, Husen M Umer, Stefan Enroth, Jan Komorowski |
Abstract |
Finding peaks in ChIP-seq is an important process in biological inference. In some cases, such as positioning nucleosomes with specific histone modifications or finding transcription factor binding specificities, the precision of the detected peak plays a significant role. There are several applications for finding peaks (called peak finders) based on different algorithms (e.g. MACS, Erange and HPeak). Benchmark studies have shown that the existing peak finders identify different peaks for the same dataset and it is not known which one is the most accurate. We present the first meta-server called Peak Finder MetaServer (PFMS) that collects results from several peak finders and produces consensus peaks. Our application accepts three standard ChIP-seq data formats: BED, BAM, and SAM. |
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