Title |
Chikungunya virus capsid protein contains nuclear import and export signals
|
---|---|
Published in |
Virology Journal, August 2013
|
DOI | 10.1186/1743-422x-10-269 |
Pubmed ID | |
Authors |
Saijo Thomas, Jagdish Rai, Lijo John, Stephan Schaefer, Brigitte M Pützer, Ottmar Herchenröder |
Abstract |
Chikungunya virus (CHIKV) is an alphavirus of the Togaviridae family. After autoproteolytic cleavage, the CHIKV capsid protein (CP) is involved in RNA binding and assembly of the viral particle. The monomeric CP is approximately 30 kDa in size and is small enough for passive transport through nuclear pores. Some alphaviruses are found to harbor nuclear localization signals (NLS) and transport of these proteins between cellular compartments was shown to be energy dependent. The active nuclear import of cytoplasmic proteins is mediated by karyopherins and their export by exportins. As nuclear and cytoplasmic trafficking may play a role in the life cycle of CHIKV, we have sought to identify nuclear localization and nuclear export signals in CHIKV CP in a virus-free system. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Norway | 1 | 1% |
Unknown | 91 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 24% |
Student > Master | 17 | 18% |
Student > Doctoral Student | 10 | 11% |
Student > Bachelor | 10 | 11% |
Researcher | 8 | 9% |
Other | 17 | 18% |
Unknown | 9 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 32% |
Biochemistry, Genetics and Molecular Biology | 22 | 24% |
Immunology and Microbiology | 8 | 9% |
Medicine and Dentistry | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 14 | 15% |
Unknown | 10 | 11% |