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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ALG-2 Attenuates COPII Budding In Vitro and Stabilizes the Sec23/Sec31A Complex
|
|---|---|
| Published in |
PLOS ONE, September 2013
|
| DOI | 10.1371/journal.pone.0075309 |
| Pubmed ID | |
| Authors |
Jonas M. la Cour, Adam J. Schindler, Martin W. Berchtold, Randy Schekman |
| Abstract |
Coated vesicles mediate the traffic of secretory and membrane cargo proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. The coat protein complex (COPII) involved in vesicle budding is constituted by a GTPase, Sar1, the inner coat components of Sec23/Sec24 and the components of the outer coat Sec13/Sec31A. The Ca(2+)-binding protein ALG-2 was recently identified as a Sec31A binding partner and a possible link to Ca(2+) regulation of COPII vesicle budding. Here we show that ALG-2/Ca(2+) is capable of attenuating vesicle budding in vitro through interaction with an ALG-2 binding domain in the proline rich region of Sec31A. Binding of ALG-2 to Sec31A and inhibition of COPII vesicle budding is furthermore dependent on an intact Ca(2+)-binding site at EF-hand 1 of ALG-2. ALG-2 increased recruitment of COPII proteins Sec23/24 and Sec13/31A to artificial liposomes and was capable of mediating binding of Sec13/31A to Sec23. These results introduce a regulatory role for ALG-2/Ca(2+) in COPII tethering and vesicle budding. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 20% |
| United Kingdom | 7 | 14% |
| Switzerland | 2 | 4% |
| Argentina | 1 | 2% |
| Australia | 1 | 2% |
| Netherlands | 1 | 2% |
| Finland | 1 | 2% |
| Italy | 1 | 2% |
| Canada | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 19 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 61% |
| Scientists | 16 | 33% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 29% |
| Student > Bachelor | 9 | 17% |
| Researcher | 6 | 12% |
| Student > Master | 5 | 10% |
| Professor | 4 | 8% |
| Other | 5 | 10% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 35% |
| Agricultural and Biological Sciences | 17 | 33% |
| Medicine and Dentistry | 5 | 10% |
| Computer Science | 1 | 2% |
| Neuroscience | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 10 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2014.
All research outputs
#1,341,136
of 25,923,151 outputs
Outputs from PLOS ONE
#16,675
of 226,236 outputs
Outputs of similar age
#11,591
of 214,645 outputs
Outputs of similar age from PLOS ONE
#444
of 4,931 outputs
Altmetric has tracked 25,923,151 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 226,236 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,645 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 4,931 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.