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The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity.

Overview of attention for article published in Diabetes, April 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 tweeters

Citations

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80 Dimensions

Readers on

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115 Mendeley
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Title
The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity.
Published in
Diabetes, April 2013
DOI 10.2337/db12-0507
Pubmed ID
Authors

Claudia P Coomans, Sjoerd A A van den Berg, Eliane A Lucassen, Thijs Houben, Amanda C M Pronk, Rianne D van der Spek, Andries Kalsbeek, Nienke R Biermasz, Ko Willems van Dijk, Johannes A Romijn, Johanna H Meijer

Abstract

Disturbances in the circadian system are associated with the development of type 2 diabetes mellitus. Here, we studied the direct contribution of the suprachiasmatic nucleus (SCN), the central pacemaker in the circadian system, in the development of insulin resistance. Exclusive bilateral SCN lesions in male C57Bl/6J mice, as verified by immunochemistry, showed a small but significant increase in body weight (+17%), which was accounted for by an increase in fat mass. In contrast, mice with collateral damage to the ventromedial hypothalamus and paraventricular nucleus showed severe obesity and insulin resistance. Mice with exclusive SCN ablation revealed a loss of circadian rhythm in activity, oxygen consumption, and food intake. Hyperinsulinemic-euglycemic clamp analysis 8 weeks after lesioning showed that the glucose infusion rate was significantly lower in SCN lesioned mice compared with sham-operated mice (-63%). Although insulin potently inhibited endogenous glucose production (-84%), this was greatly reduced in SCN lesioned mice (-7%), indicating severe hepatic insulin resistance. Our data show that SCN malfunctioning plays an important role in the disturbance of energy balance and suggest that an absence of central clock activity, in a genetically intact animal, may lead to the development of insulin resistance.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russian Federation 1 <1%
Portugal 1 <1%
Mexico 1 <1%
Brazil 1 <1%
United States 1 <1%
Sweden 1 <1%
Canada 1 <1%
Colombia 1 <1%
Unknown 107 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 26%
Student > Master 18 16%
Researcher 13 11%
Student > Doctoral Student 12 10%
Student > Bachelor 10 9%
Other 32 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 43%
Medicine and Dentistry 26 23%
Unspecified 9 8%
Biochemistry, Genetics and Molecular Biology 9 8%
Neuroscience 9 8%
Other 12 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2013.
All research outputs
#3,851,493
of 8,826,251 outputs
Outputs from Diabetes
#2,501
of 4,206 outputs
Outputs of similar age
#50,792
of 143,722 outputs
Outputs of similar age from Diabetes
#8
of 14 outputs
Altmetric has tracked 8,826,251 research outputs across all sources so far. This one has received more attention than most of these and is in the 55th percentile.
So far Altmetric has tracked 4,206 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,722 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.