↓ Skip to main content

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

Overview of attention for article published in Nature Communications, March 2017
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

news
4 news outlets
twitter
56 tweeters

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
120 Mendeley
Title
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Published in
Nature Communications, March 2017
DOI 10.1038/ncomms14764
Pubmed ID
Authors

Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva

Abstract

The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug discovery. Here we describe the crystal structure of the recombinant ZIKV NS5 RdRp domain at 1.9 Å resolution as a platform for structure-based drug design strategy. The overall structure is similar to other flaviviral homologues. However, the priming loop target site, which is suitable for non-nucleoside polymerase inhibitor design, shows significant differences in comparison with the dengue virus structures, including a tighter pocket and a modified local charge distribution.

Twitter Demographics

The data shown below were collected from the profiles of 56 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Brazil 1 <1%
Unknown 118 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 27 23%
Researcher 21 18%
Student > Master 17 14%
Unspecified 15 13%
Student > Ph. D. Student 15 13%
Other 25 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 27%
Agricultural and Biological Sciences 25 21%
Unspecified 20 17%
Chemistry 17 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Other 19 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2017.
All research outputs
#219,166
of 13,365,928 outputs
Outputs from Nature Communications
#4,063
of 23,737 outputs
Outputs of similar age
#9,458
of 261,980 outputs
Outputs of similar age from Nature Communications
#285
of 1,093 outputs
Altmetric has tracked 13,365,928 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,737 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,980 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,093 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.