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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

Overview of attention for article published in Nature Communications, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

news
4 news outlets
twitter
53 tweeters

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
133 Mendeley
Title
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Published in
Nature Communications, March 2017
DOI 10.1038/ncomms14764
Pubmed ID
Authors

Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva

Abstract

The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug discovery. Here we describe the crystal structure of the recombinant ZIKV NS5 RdRp domain at 1.9 Å resolution as a platform for structure-based drug design strategy. The overall structure is similar to other flaviviral homologues. However, the priming loop target site, which is suitable for non-nucleoside polymerase inhibitor design, shows significant differences in comparison with the dengue virus structures, including a tighter pocket and a modified local charge distribution.

Twitter Demographics

The data shown below were collected from the profiles of 53 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Spain 1 <1%
Unknown 130 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 29 22%
Researcher 25 19%
Student > Master 21 16%
Student > Ph. D. Student 16 12%
Professor > Associate Professor 8 6%
Other 19 14%
Unknown 15 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 29%
Agricultural and Biological Sciences 26 20%
Chemistry 20 15%
Medicine and Dentistry 7 5%
Immunology and Microbiology 6 5%
Other 15 11%
Unknown 20 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2017.
All research outputs
#256,712
of 14,171,024 outputs
Outputs from Nature Communications
#4,711
of 26,341 outputs
Outputs of similar age
#10,063
of 263,576 outputs
Outputs of similar age from Nature Communications
#297
of 1,087 outputs
Altmetric has tracked 14,171,024 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,341 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,576 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,087 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.