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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
|
|---|---|
| Published in |
Nature Communications, March 2017
|
| DOI | 10.1038/ncomms14764 |
| Pubmed ID | |
| Authors |
Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva |
| Abstract |
The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug discovery. Here we describe the crystal structure of the recombinant ZIKV NS5 RdRp domain at 1.9 Å resolution as a platform for structure-based drug design strategy. The overall structure is similar to other flaviviral homologues. However, the priming loop target site, which is suitable for non-nucleoside polymerase inhibitor design, shows significant differences in comparison with the dengue virus structures, including a tighter pocket and a modified local charge distribution. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 10 | 23% |
| United Kingdom | 3 | 7% |
| Germany | 3 | 7% |
| Sweden | 1 | 2% |
| Chile | 1 | 2% |
| Poland | 1 | 2% |
| Japan | 1 | 2% |
| United States | 1 | 2% |
| Canada | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 19 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 65% |
| Scientists | 13 | 30% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| Spain | 1 | <1% |
| Unknown | 204 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 38 | 18% |
| Researcher | 30 | 14% |
| Student > Master | 26 | 13% |
| Student > Ph. D. Student | 24 | 12% |
| Student > Doctoral Student | 14 | 7% |
| Other | 28 | 14% |
| Unknown | 47 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 46 | 22% |
| Chemistry | 31 | 15% |
| Agricultural and Biological Sciences | 31 | 15% |
| Immunology and Microbiology | 10 | 5% |
| Medicine and Dentistry | 8 | 4% |
| Other | 24 | 12% |
| Unknown | 57 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#651,608
of 25,758,695 outputs
Outputs from Nature Communications
#11,241
of 58,347 outputs
Outputs of similar age
#13,215
of 324,082 outputs
Outputs of similar age from Nature Communications
#252
of 842 outputs
Altmetric has tracked 25,758,695 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,347 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,082 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 842 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.