T Cell Polarization toward TH2/TFH2 and TH17/TFH17 in Patients with IgG4-Related Disease

Mast cell activation is a treatable Th2 condition.

https://t.co/i5rARi1Opa "Both PD1+ Tfh2 and Tfh17 subsets have been shown to be prone to migrate into B cell follicles and/or inflammatory sites and could therefore contribute to B cell activation and IgG4 class switch in IgG4-RD tissues."

https://t.co/i5rARi1Opa "Circulating PD1+ TFH are expanded together with TH2 and TH17, associated with elevated IL-4, IL-10, and IL-17 release."

https://t.co/i5rARi1Opa "We show that patients with active, untreated IgG4-RD presenting with variable organ involvements present specific changes of T cells in peripheral blood."