Title |
A methamphetamine analog (N,α‐diethyl‐phenylethylamine) identified in a mainstream dietary supplement
|
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Published in |
Drug Testing and Analysis, October 2013
|
DOI | 10.1002/dta.1578 |
Pubmed ID | |
Authors |
Pieter A. Cohen, John C. Travis, Bastiaan J. Venhuis |
Abstract |
Pharmaceuticals and banned substances have been detected in hundreds of purportedly natural supplements. Recently, several athletes have been disqualified from competition after testing positive for the methamphetamine analog N,α-diethyl-phenylethylamine (N,α-DEPEA). Athletes have claimed they unknowingly consumed the banned stimulant in workout supplements. Three samples from different lot numbers of Craze, a workout supplement, were analyzed to detect the presence and concentration of N,α-DEPEA. Two labs independently identified N,α-DEPEA in the supplement using ultra high performance liquid chromatography (UHPLC) coupled to an LTQ Orbitrap XL mass spectrometer and UHPLC-quadruple-time-of-flight mass (Q-TOF) spectrometer, respectively. The identity of N,α-DEPEA was confirmed using nuclear magnetic resonance and reference standards. Manufacturer recommended servings were estimated to provide 21 to 35 mg of N,α-DEPEA. N,α-DEPEA has never been studied in humans. N,α-DEPEA is a methamphetamine analog; however, its stimulant, addictive and other adverse effects in humans are entirely unknown. Regulatory agencies should act expeditiously to warn consumers and remove N,α-DEPEA from all dietary supplements. Copyright © 2013 John Wiley & Sons, Ltd. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 14 | 19% |
United Kingdom | 11 | 15% |
Australia | 5 | 7% |
Canada | 4 | 6% |
Belgium | 3 | 4% |
Spain | 2 | 3% |
Japan | 1 | 1% |
Côte d'Ivoire | 1 | 1% |
Ghana | 1 | 1% |
Other | 6 | 8% |
Unknown | 24 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 40 | 56% |
Practitioners (doctors, other healthcare professionals) | 16 | 22% |
Scientists | 14 | 19% |
Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 4% |
United Kingdom | 1 | 1% |
Unknown | 77 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 18 | 22% |
Researcher | 9 | 11% |
Student > Bachelor | 8 | 10% |
Student > Ph. D. Student | 8 | 10% |
Other | 7 | 9% |
Other | 11 | 14% |
Unknown | 20 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 15% |
Medicine and Dentistry | 11 | 14% |
Chemistry | 11 | 14% |
Sports and Recreations | 6 | 7% |
Social Sciences | 5 | 6% |
Other | 14 | 17% |
Unknown | 22 | 27% |