Title |
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration
|
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Published in |
Breast Cancer Research, September 2013
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DOI | 10.1186/bcr3487 |
Pubmed ID | |
Authors |
Kristi Bray, Melissa Gillette, Jeanette Young, Elizabeth Loughran, Melissa Hwang, James Cooper Sears, Tracy Vargo-Gogola |
Abstract |
The Rho GTPase Cdc42 is overexpressed and hyperactivated in breast tumors compared to normal breast tissue. Cdc42 regulates key processes that are critical for mammary gland morphogenesis and become disrupted during the development, progression, and metastasis of breast cancer. However, the contribution of Cdc42 to normal and neoplastic mammary gland development in vivo remains poorly understood. We were therefore interested in investigating the effects of Cdc42 overexpression on mammary gland morphogenesis as a first step toward understanding how its overexpression may contribute to mammary tumorigenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 27% |
Student > Master | 12 | 20% |
Student > Doctoral Student | 5 | 8% |
Student > Bachelor | 5 | 8% |
Researcher | 5 | 8% |
Other | 3 | 5% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 37% |
Biochemistry, Genetics and Molecular Biology | 11 | 18% |
Medicine and Dentistry | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Physics and Astronomy | 2 | 3% |
Other | 3 | 5% |
Unknown | 16 | 27% |