Title |
Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats
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Published in |
Lipids in Health and Disease, October 2013
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DOI | 10.1186/1476-511x-12-146 |
Pubmed ID | |
Authors |
Fabíola Iagher, Sérgio Ricardo de Brito Belo, Wanessa Mazanek Souza, Juliana Rehlander Nunes, Katya Naliwaiko, Guilherme Lanzi Sassaki, Sandro José Ribeiro Bonatto, Heloísa Helena Paro de Oliveira, Gleisson Alisson Pereira Brito, Carina de Lima, Marcelo Kryczyk, Carine Ferreira de Souza, Jovani Antonio Steffani, Everson Araújo Nunes, Luiz Cláudio Fernandes |
Abstract |
Shark liver oil (SLOil) and fish oil (FOil), which are respectively rich in alkylglycerols (AKGs) and n-3 polyunsaturated fatty acids (PUFAs), are able to reduce the growth of some tumors and the burden of cachexia. It is known that FOil is able to reduce proliferation rate and increase apoptotic cells and lipid peroxidation of tumor cells efficiently. However, there are few reports revealing the influence of SLOil on these parameters. In the current study, effects of FOil chronic supplementation on tumor growth and cachexia were taken as reference to compare the results obtained with SLOil supplementation. Also, we evaluated if the association of SLOil and FOil was able to promote additive effects. |
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