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Sleep Drives Metabolite Clearance from the Adult Brain

Overview of attention for article published in Science, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#26 of 61,121)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1230 Dimensions

Readers on

mendeley
2608 Mendeley
citeulike
19 CiteULike
Title
Sleep Drives Metabolite Clearance from the Adult Brain
Published in
Science, October 2013
DOI 10.1126/science.1241224
Pubmed ID
Authors

L. Xie, H. Kang, Q. Xu, M. J. Chen, Y. Liao, M. Thiyagarajan, J. O'Donnell, D. J. Christensen, C. Nicholson, J. J. Iliff, T. Takano, R. Deane, M. Nedergaard

Abstract

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

Twitter Demographics

The data shown below were collected from the profiles of 1,663 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2,608 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 88 3%
United Kingdom 21 <1%
Japan 15 <1%
Germany 10 <1%
Canada 10 <1%
Netherlands 9 <1%
Brazil 8 <1%
France 8 <1%
Denmark 5 <1%
Other 62 2%
Unknown 2372 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 625 24%
Researcher 489 19%
Student > Bachelor 397 15%
Student > Master 321 12%
Unspecified 133 5%
Other 643 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 769 29%
Medicine and Dentistry 487 19%
Neuroscience 396 15%
Psychology 255 10%
Unspecified 247 9%
Other 454 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2834. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2019.
All research outputs
#285
of 13,090,703 outputs
Outputs from Science
#26
of 61,121 outputs
Outputs of similar age
#5
of 179,432 outputs
Outputs of similar age from Science
#2
of 879 outputs
Altmetric has tracked 13,090,703 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 61,121 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 879 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.