↓ Skip to main content

Sleep Drives Metabolite Clearance from the Adult Brain

Overview of attention for article published in Science, October 2013
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

dimensions_citation
2626 Dimensions

Readers on

mendeley
4102 Mendeley
citeulike
19 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Sleep Drives Metabolite Clearance from the Adult Brain
Published in
Science, October 2013
DOI 10.1126/science.1241224
Pubmed ID
Authors

Lulu Xie, Hongyi Kang, Qiwu Xu, Michael J. Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O’Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff, Takahiro Takano, Rashid Deane, Maiken Nedergaard

Abstract

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

Twitter Demographics

The data shown below were collected from the profiles of 1,916 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4,102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 81 2%
United Kingdom 19 <1%
Japan 15 <1%
Netherlands 9 <1%
Canada 9 <1%
France 7 <1%
Germany 7 <1%
Brazil 7 <1%
Italy 5 <1%
Other 60 1%
Unknown 3883 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 837 20%
Researcher 658 16%
Student > Bachelor 598 15%
Student > Master 489 12%
Other 207 5%
Other 767 19%
Unknown 546 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 821 20%
Neuroscience 750 18%
Medicine and Dentistry 641 16%
Psychology 324 8%
Biochemistry, Genetics and Molecular Biology 226 6%
Other 598 15%
Unknown 742 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3360. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2022.
All research outputs
#1,404
of 21,815,602 outputs
Outputs from Science
#88
of 76,939 outputs
Outputs of similar age
#5
of 207,896 outputs
Outputs of similar age from Science
#2
of 847 outputs
Altmetric has tracked 21,815,602 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 76,939 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 60.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,896 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 847 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.