Sleep Drives Metabolite Clearance from the Adult Brain

Overview of attention for article published in Science, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 39,149)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
1780 Mendeley
citeulike
17 CiteULike
Title
Sleep Drives Metabolite Clearance from the Adult Brain
Published in
Science, October 2013
DOI 10.1126/science.1241224
Pubmed ID
Authors

Lulu Xie, Hongyi Kang, Qiwu Xu, Michael J. Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O’Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff, Takahiro Takano, Rashid Deane, Maiken Nedergaard, Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M

Abstract

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

Twitter Demographics

The data shown below were collected from the profiles of 1,633 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,780 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 96 5%
United Kingdom 23 1%
Japan 14 <1%
Germany 13 <1%
Canada 10 <1%
France 9 <1%
Netherlands 9 <1%
Brazil 8 <1%
Italy 7 <1%
Other 66 4%
Unknown 1525 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 483 27%
Researcher 356 20%
Student > Bachelor 245 14%
Student > Master 228 13%
Professor > Associate Professor 104 6%
Other 364 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 771 43%
Medicine and Dentistry 393 22%
Psychology 187 11%
Neuroscience 158 9%
Engineering 61 3%
Other 210 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2600. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2017.
All research outputs
#105
of 7,431,303 outputs
Outputs from Science
#6
of 39,149 outputs
Outputs of similar age
#4
of 140,314 outputs
Outputs of similar age from Science
#2
of 811 outputs
Altmetric has tracked 7,431,303 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 39,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,314 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 811 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.