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Sleep Drives Metabolite Clearance from the Adult Brain

Overview of attention for article published in Science, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1988 Dimensions

Readers on

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3594 Mendeley
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19 CiteULike
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Title
Sleep Drives Metabolite Clearance from the Adult Brain
Published in
Science, October 2013
DOI 10.1126/science.1241224
Pubmed ID
Authors

L. Xie, H. Kang, Q. Xu, M. J. Chen, Y. Liao, M. Thiyagarajan, J. O'Donnell, D. J. Christensen, C. Nicholson, J. J. Iliff, T. Takano, R. Deane, M. Nedergaard

Abstract

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

Twitter Demographics

The data shown below were collected from the profiles of 1,979 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3,594 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 83 2%
United Kingdom 20 <1%
Japan 15 <1%
Netherlands 9 <1%
Canada 9 <1%
Brazil 8 <1%
France 8 <1%
Germany 7 <1%
Italy 5 <1%
Other 60 2%
Unknown 3370 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 784 22%
Researcher 612 17%
Student > Bachelor 538 15%
Student > Master 437 12%
Other 184 5%
Other 692 19%
Unknown 347 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 818 23%
Neuroscience 661 18%
Medicine and Dentistry 595 17%
Psychology 305 8%
Biochemistry, Genetics and Molecular Biology 198 6%
Other 502 14%
Unknown 515 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3297. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2021.
All research outputs
#821
of 17,433,323 outputs
Outputs from Science
#56
of 70,777 outputs
Outputs of similar age
#4
of 193,568 outputs
Outputs of similar age from Science
#2
of 881 outputs
Altmetric has tracked 17,433,323 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 70,777 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 54.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,568 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 881 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.