Title |
The application of hyaluronic acid-derivatized carbon nanotubes in hematoporphyrin monomethyl ether-based photodynamic therapy for in vivo and in vitro cancer treatment
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Published in |
International Journal of Nanomedicine, July 2013
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DOI | 10.2147/ijn.s45407 |
Pubmed ID | |
Authors |
Jinjin Shi, Rourou Ma, Lei Wang, Jing Zhang, Ruiyuan Liu, Lulu Li, Yan Liu, Lin Hou, Xiaoyuan Yu, Jun Gao, Zhenzhong Zhang |
Abstract |
Carbon nanotubes (CNTs) have shown great potential in both photothermal therapy and drug delivery. In this study, a CNT derivative, hyaluronic acid-derivatized CNTs (HA-CNTs) with high aqueous solubility, neutral pH, and tumor-targeting activity, were synthesized and characterized, and then a new photodynamic therapy agent, hematoporphyrin monomethyl ether (HMME), was adsorbed onto the functionalized CNTs to develop HMME-HA-CNTs. Tumor growth inhibition was investigated both in vivo and in vitro by a combination of photothermal therapy and photodynamic therapy using HMME-HA-CNTs. The ability of HMME-HA-CNT nanoparticles to combine local specific photodynamic therapy with external near-infrared photothermal therapy significantly improved the therapeutic efficacy of cancer treatment. Compared with photodynamic therapy or photothermal therapy alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy without obvious toxic effects to normal organs. Overall, it was demonstrated that HMME-HA-CNTs could be successfully applied to photodynamic therapy and photothermal therapy simultaneously in future tumor therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 61 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 19% |
Student > Master | 12 | 19% |
Researcher | 9 | 14% |
Student > Bachelor | 6 | 10% |
Student > Doctoral Student | 2 | 3% |
Other | 9 | 14% |
Unknown | 13 | 21% |
Readers by discipline | Count | As % |
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Chemistry | 12 | 19% |
Medicine and Dentistry | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Agricultural and Biological Sciences | 4 | 6% |
Other | 14 | 22% |
Unknown | 14 | 22% |