Title |
Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis
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Published in |
BMC Genomics, August 2013
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DOI | 10.1186/1471-2164-14-589 |
Pubmed ID | |
Authors |
Silvia Pizzini, Andrea Bisognin, Susanna Mandruzzato, Marta Biasiolo, Arianna Facciolli, Lisa Perilli, Elisabetta Rossi, Giovanni Esposito, Massimo Rugge, Pierluigi Pilati, Simone Mocellin, Donato Nitti, Stefania Bortoluzzi, Paola Zanovello |
Abstract |
Qualitative alterations or abnormal expression of microRNAs (miRNAs) in colon cancer have mainly been demonstrated in primary tumors. Poorly overlapping sets of oncomiRs, tumor suppressor miRNAs and metastamiRs have been linked with distinct stages in the progression of colorectal cancer. To identify changes in both miRNA and gene expression levels among normal colon mucosa, primary tumor and liver metastasis samples, and to classify miRNAs into functional networks, in this work miRNA and gene expression profiles in 158 samples from 46 patients were analysed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | <1% |
Germany | 1 | <1% |
Malaysia | 1 | <1% |
Brazil | 1 | <1% |
India | 1 | <1% |
Denmark | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Luxembourg | 1 | <1% |
Other | 0 | 0% |
Unknown | 108 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 21% |
Researcher | 21 | 18% |
Student > Master | 17 | 15% |
Other | 11 | 9% |
Student > Postgraduate | 9 | 8% |
Other | 20 | 17% |
Unknown | 15 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 26% |
Biochemistry, Genetics and Molecular Biology | 25 | 21% |
Medicine and Dentistry | 22 | 19% |
Immunology and Microbiology | 6 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 10 | 9% |
Unknown | 20 | 17% |