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Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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Title
Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20175670
Pubmed ID
Authors

R.F. Leoni, I.A.F. Oliveira, O.M. Pontes-Neto, A.C. Santos, J.P. Leite

Abstract

Regional cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in young and elderly participants were assessed using pulsed arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) techniques in combination with inhalation of CO2. Pulsed ASL and BOLD-MRI were acquired in seventeen asymptomatic volunteers (10 young adults, age: 30±7 years; 7 elderly adults, age: 64±8 years) with no history of diabetes, hypertension, and neurological diseases. Data from one elderly participant was excluded due to the incorrigible head motion. Average baseline CBF in gray matter was significantly reduced in elderly (46±9 mL·100 g-1·min-1) compared to young adults (57±8 mL·100 g-1·min-1; P=0.02). Decreased pulsed ASL-CVR and BOLD-CVR in gray matter were also observed in elderly (2.12±1.30 and 0.13±0.06 %/mmHg, respectively) compared to young adults (3.28±1.43 and 0.28±0.11 %/mmHg, respectively; P<0.05), suggesting some degree of vascular impairment with aging. Moreover, age-related decrease in baseline CBF was observed in different brain regions (inferior, middle and superior frontal gyri; precentral and postcentral gyri; superior temporal gyrus; cingulate gyri; insula, putamen, caudate, and supramarginal gyrus). In conclusion, CBF and CVR were successfully investigated using a protocol that causes minimal or no discomfort for the participants. Age-related decreases in baseline CBF and CVR were observed in the cerebral cortex, which may be related to the vulnerability for neurological disorders in aging.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Portugal 1 1%
Canada 1 1%
Unknown 82 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 18%
Student > Ph. D. Student 14 16%
Student > Bachelor 10 12%
Researcher 9 11%
Other 7 8%
Other 14 16%
Unknown 16 19%
Readers by discipline Count As %
Neuroscience 17 20%
Medicine and Dentistry 15 18%
Nursing and Health Professions 4 5%
Engineering 3 4%
Agricultural and Biological Sciences 3 4%
Other 14 16%
Unknown 29 34%