Title |
Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses
|
---|---|
Published in |
Biology of Mood & Anxiety Disorders, October 2013
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DOI | 10.1186/2045-5380-3-19 |
Pubmed ID | |
Authors |
Matthew N Hill, Sachin Patel |
Abstract |
Accumulating evidence over the past decade has highlighted an important role of the endocannabinoid (eCB) system in the regulation of stress and emotional behavior across divergent species, from rodents to humans. The general findings from this work indicate that the eCB system plays an important role in gating and buffering the stress response, dampening anxiety and regulating mood. Work in rodents has allowed researchers to determine the neural mechanisms mediating this relationship while work in human populations has demonstrated the possible importance of this system in stress-related psychiatric diseases, such as post-traumatic stress disorder, generalized anxiety and major depression. These stress-protective effects of eCB signaling appear to be primarily mediated by their actions within corticolimbic structures, particularly the amygdala and the prefrontal cortex. The aim of this review is to provide an up-to-date discussion of the current level of knowledge in this field, as well as address the current gaps in knowledge and specific areas of research that require attention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 33% |
United States | 1 | 11% |
Malta | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 67% |
Scientists | 2 | 22% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 177 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 31 | 17% |
Student > Bachelor | 28 | 15% |
Student > Ph. D. Student | 23 | 13% |
Student > Master | 17 | 9% |
Student > Doctoral Student | 11 | 6% |
Other | 30 | 16% |
Unknown | 42 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 37 | 20% |
Agricultural and Biological Sciences | 28 | 15% |
Medicine and Dentistry | 19 | 10% |
Psychology | 15 | 8% |
Biochemistry, Genetics and Molecular Biology | 12 | 7% |
Other | 20 | 11% |
Unknown | 51 | 28% |