Title |
Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview
|
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Published in |
Journal of Venomous Animals and Toxins including Tropical Diseases, April 2017
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DOI | 10.1186/s40409-017-0109-8 |
Pubmed ID | |
Authors |
Rui Seabra Ferreira, Luciana Curtolo de Barros, Luciana Patrícia Fernandes Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Leticia Gomes de Pontes, Lucilene Delazari dos Santos, Benedito Barraviera |
Abstract |
Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 67% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 1% |
Unknown | 74 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 17% |
Researcher | 9 | 12% |
Student > Ph. D. Student | 8 | 11% |
Student > Doctoral Student | 7 | 9% |
Student > Master | 7 | 9% |
Other | 10 | 13% |
Unknown | 21 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 16% |
Agricultural and Biological Sciences | 11 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Neuroscience | 3 | 4% |
Other | 12 | 16% |
Unknown | 29 | 39% |