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Complete Factor I Deficiency Due to Dysfunctional Factor I with Recurrent Aseptic Meningo-Encephalitis

Overview of attention for article published in Journal of Clinical Immunology, October 2013
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Title
Complete Factor I Deficiency Due to Dysfunctional Factor I with Recurrent Aseptic Meningo-Encephalitis
Published in
Journal of Clinical Immunology, October 2013
DOI 10.1007/s10875-013-9944-8
Pubmed ID
Authors

Filomeen Haerynck, Patrick Stordeur, Johan Vandewalle, Rudy Van Coster, Victoria Bordon, Frans De Baets, Petra Schelstraete, Cédric Javaux, Marie-Rose Bouvry, Véronique Fremeaux-Bacchi, Joke Dehoorne

Abstract

Complement regulators control the activated complement system. Defects in this homeostasis can result in tissue damage and autoimmune diseases with a heterogeneity in clinical presentation. Complement factor I (FI), a serine protease, is an important regulator of alternative pathway activation. We report a diagnostic work-up of a patient with relapsing inflammatory mediated meningo-encephalitis. Our work-up revealed a rare genetic factor I (FI) deficiency. So far, all cases of reported complete factor I deficiency have absent serum levels of FI. We present here a unique case of a complete factor I deficiency based on a functional FI defect.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 22%
Student > Ph. D. Student 4 22%
Student > Bachelor 2 11%
Other 2 11%
Student > Doctoral Student 1 6%
Other 3 17%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Agricultural and Biological Sciences 3 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 17%
Psychology 1 6%
Immunology and Microbiology 1 6%
Other 0 0%
Unknown 3 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2014.
All research outputs
#20,207,295
of 22,727,570 outputs
Outputs from Journal of Clinical Immunology
#1,254
of 1,560 outputs
Outputs of similar age
#184,794
of 211,692 outputs
Outputs of similar age from Journal of Clinical Immunology
#11
of 17 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,560 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.