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IAP proteins as targets for drug development in oncology

Overview of attention for article published in OncoTargets and therapy, September 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

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1 tweeter
patent
1 patent

Citations

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99 Dimensions

Readers on

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99 Mendeley
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Title
IAP proteins as targets for drug development in oncology
Published in
OncoTargets and therapy, September 2013
DOI 10.2147/ott.s33375
Pubmed ID
Authors

Laurence Dubrez, Jean Berthelet, Valérie Glorian

Abstract

The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or radiotherapy because of the presence of an internal ribosome entry site (IRES)-dependent mechanism of translation initiation, which could contribute to resistance to antitumor therapy. The development of IAP antagonists is an important challenge and was subject to intense research over the past decade. Six molecules are currently in clinical trials. This review focuses on the role of IAPs in tumors and the development of IAP-targeting molecules for anticancer therapy.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Mexico 1 1%
Netherlands 1 1%
Unknown 95 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 20%
Student > Master 18 18%
Student > Bachelor 14 14%
Researcher 10 10%
Other 6 6%
Other 12 12%
Unknown 19 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 27%
Biochemistry, Genetics and Molecular Biology 14 14%
Pharmacology, Toxicology and Pharmaceutical Science 10 10%
Medicine and Dentistry 10 10%
Chemistry 8 8%
Other 7 7%
Unknown 23 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2023.
All research outputs
#7,110,337
of 23,245,494 outputs
Outputs from OncoTargets and therapy
#376
of 2,961 outputs
Outputs of similar age
#61,194
of 201,349 outputs
Outputs of similar age from OncoTargets and therapy
#9
of 35 outputs
Altmetric has tracked 23,245,494 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,961 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,349 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.