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Role of a GenoType MTBDRplus line probe assay in early detection of multidrug-resistant tuberculosis at a Brazilian reference center

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, August 2015
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Title
Role of a GenoType MTBDRplus line probe assay in early detection of multidrug-resistant tuberculosis at a Brazilian reference center
Published in
Brazilian Journal of Medical and Biological Research, August 2015
DOI 10.1590/1414-431x20154458
Pubmed ID
Authors

C.S. Feliciano, M.M.P. Nascimento, L.M.P. Anselmo, R.H.C. Pocente, F. Bellissimo-Rodrigues, V.R. Bollela

Abstract

Resistance to Mycobacterium tuberculosis is a reality worldwide, and its diagnosis continues to be difficult and time consuming. To face this challenge, the World Health Organization has recommended the use of rapid molecular tests. We evaluated the routine use (once a week) of a line probe assay (Genotype MTBDRplus) for early diagnosis of resistance and for assessment of the main related risk factors over 2 years. A total of 170 samples were tested: 15 (8.8%) were resistant, and multidrug resistance was detected in 10 (5.9%). The sensitivity profile took 3 weeks (2 weeks for culture and 1 week for rapid testing). Previous treatment for tuberculosis and the persistence of positive acid-fast smears after 4 months of supervised treatment were the major risk factors observed. The use of molecular tests enabled early diagnosis of drug-resistant bacilli and led to appropriate treatment of the disease. This information has the potential to interrupt the transmission chain of resistant M. tuberculosis.

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Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 25%
Researcher 8 13%
Student > Bachelor 6 10%
Other 5 8%
Student > Ph. D. Student 5 8%
Other 13 21%
Unknown 9 15%
Readers by discipline Count As %
Medicine and Dentistry 22 36%
Immunology and Microbiology 6 10%
Agricultural and Biological Sciences 5 8%
Biochemistry, Genetics and Molecular Biology 4 7%
Nursing and Health Professions 3 5%
Other 9 15%
Unknown 12 20%