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Upregulation of microRNA 142-3p in the peripheral blood and urinary cells of kidney transplant recipients with post-transplant graft dysfunction

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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Title
Upregulation of microRNA 142-3p in the peripheral blood and urinary cells of kidney transplant recipients with post-transplant graft dysfunction
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20175533
Pubmed ID
Authors

T.D. Domenico, G. Joelsons, R.M. Montenegro, R.C. Manfro

Abstract

We analyzed microRNA (miR)-142-3p expression in leucocytes of the peripheral blood and urinary sediment cell samples obtained from kidney transplant recipients who developed graft dysfunction. Forty-one kidney transplant recipients with kidney graft dysfunction and 8 stable patients were included in the study. The groups were divided according to histological analysis into acute rejection group (n=23), acute tubular necrosis group (n=18) and stable patients group used as a control for gene expression (n=8). Percutaneous biopsies were performed and peripheral blood samples and urine samples were obtained. miR-142-3p was analyzed by real-time polymerase chain reaction. The group of patients with acute tubular necrosis presented significantly higher expressions in peripheral blood (P<0.05) and urine (P<0.001) compared to the stable patients group. Also, in the peripheral blood, miR-142-3p expression was significantly higher in the acute tubular necrosis group compared to the acute rejection group (P<0.05). Urine samples of the acute rejection group presented higher expression compared to the stable patients group (P<0.001) but the difference between acute tubular necrosis and acute rejection groups was not significant in the urinary analyzes (P=0.079). miR-142-3p expression has a distinct pattern of expression in the setting of post-operative acute tubular necrosis after kidney transplantation and may potentially be used as a non-invasive biomarker for renal graft dysfunction.

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Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 23%
Student > Master 4 15%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 2 8%
Lecturer 2 8%
Other 5 19%
Unknown 4 15%
Readers by discipline Count As %
Medicine and Dentistry 6 23%
Biochemistry, Genetics and Molecular Biology 3 12%
Immunology and Microbiology 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Computer Science 1 4%
Other 4 15%
Unknown 9 35%