Title |
Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response
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Published in |
Retrovirology, October 2013
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DOI | 10.1186/1742-4690-10-110 |
Pubmed ID | |
Authors |
Cheila Rocha, Rita Calado, Pedro Borrego, José Maria Marcelino, Inês Bártolo, Lino Rosado, Patrícia Cavaco-Silva, Perpétua Gomes, Carlos Família, Alexandre Quintas, Helena Skar, Thomas Leitner, Helena Barroso, Nuno Taveira |
Abstract |
Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4⁺ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and resulting HIV-2 escape during acute infection and their impact in HIV-2 evolution and disease progression remain largely unknown. Our objective was to characterize the Nab response and the molecular and phenotypic evolution of HIV-2 in association with Nab escape in the first years of infection in two children infected at birth. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Portugal | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 22% |
Student > Master | 8 | 15% |
Student > Ph. D. Student | 6 | 11% |
Student > Bachelor | 6 | 11% |
Student > Postgraduate | 4 | 7% |
Other | 11 | 20% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 18% |
Immunology and Microbiology | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Chemistry | 3 | 5% |
Other | 9 | 16% |
Unknown | 10 | 18% |