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Production of human blood group B antigen epitope conjugated protein in Escherichia coli and utilization of the adsorption blood group B antibody

Overview of attention for article published in Microbial Cell Factories, August 2016
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3 tweeters

Citations

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5 Dimensions

Readers on

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17 Mendeley
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Title
Production of human blood group B antigen epitope conjugated protein in Escherichia coli and utilization of the adsorption blood group B antibody
Published in
Microbial Cell Factories, August 2016
DOI 10.1186/s12934-016-0538-z
Pubmed ID
Authors

Wenjing Shang, Yafei Zhai, Zhongrui Ma, Gongjin Yang, Yan Ding, Donglei Han, Jiang Li, Houcheng Zhang, Jun Liu, Peng George Wang, Xian-wei Liu, Min Chen

Abstract

In the process of ABO-incompatible (ABOi) organ transplantation, removal of anti-A and/or B antibodies from blood plasma is a promising method to overcome hyperacute rejection and allograft loss caused by the immune response between anti-A and/or B antibodies and the A and/or B antigens in the recipient. Although there are commercial columns to do this work, the application is still limited because of the high production cost. In this study, the PglB glycosylation pathway from Campylobacter jejuni was exploited to produce glycoprotein conjugated with Escherichia coli O86:B7 O-antigen, which bears the blood group B antigen epitope to absorb blood group B antibody in blood. The titers of blood group B antibody were reduced to a safe level without changing the clotting function of plasma after glycoprotein absorption of B antibodies in the plasma. We developed a feasible strategy for the specific adsorption/removal of blood group antibodies. This method will be useful in ABOi organ transplantation and universal blood transfusion.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 35%
Student > Ph. D. Student 3 18%
Student > Doctoral Student 2 12%
Professor 1 6%
Student > Master 1 6%
Other 2 12%
Unknown 2 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 29%
Biochemistry, Genetics and Molecular Biology 5 29%
Chemical Engineering 2 12%
Immunology and Microbiology 2 12%
Medicine and Dentistry 1 6%
Other 0 0%
Unknown 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2017.
All research outputs
#7,845,118
of 12,502,636 outputs
Outputs from Microbial Cell Factories
#532
of 918 outputs
Outputs of similar age
#147,425
of 257,809 outputs
Outputs of similar age from Microbial Cell Factories
#1
of 2 outputs
Altmetric has tracked 12,502,636 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 918 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,809 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them