Title |
Modeling of the human rhinovirus C capsid suggests a novel topography with insights on receptor preference and immunogenicity
|
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Published in |
Virology, October 2013
|
DOI | 10.1016/j.virol.2013.10.006 |
Pubmed ID | |
Authors |
Holly A. Basta, Jean-Yves Sgro, Ann C. Palmenberg |
Abstract |
Features of human rhinovirus (RV)-C virions that allow them to use novel cell receptors and evade immune responses are unknown. Unlike the RV-A+B, these isolates cannot be propagated in typical culture systems or grown for structure studies. Comparative sequencing, I-TASSER, MODELLER, ROBETTA, and refined alignment techniques led to a structural approximation for C15 virions, based on the extensive, resolved RV-A+B datasets. The model predicts that all RV-C VP1 proteins are shorter by 21 residues relative to the RV-A, and 35 residues relative to the RV-B, effectively shaving the RV 5-fold plateau from the particle. There are major alterations in VP1 neutralizing epitopes and the structural determinants for ICAM-1 and LDLR receptors. The VP2 and VP3 elements are similar among all RV, but the loss of sequence "words" contributing Nim1ab has increased the apparent selective pressure among the RV-C to fix mutations elsewhere in the VP1, creating a possible compensatory epitope. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 33% |
Spain | 1 | 33% |
United States | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
India | 1 | 2% |
Netherlands | 1 | 2% |
Australia | 1 | 2% |
Unknown | 58 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 19% |
Student > Bachelor | 11 | 18% |
Researcher | 10 | 16% |
Student > Master | 6 | 10% |
Student > Postgraduate | 5 | 8% |
Other | 9 | 15% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 29% |
Medicine and Dentistry | 11 | 18% |
Biochemistry, Genetics and Molecular Biology | 10 | 16% |
Chemistry | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 7 | 11% |
Unknown | 10 | 16% |