Modeling of the human rhinovirus C capsid suggests a novel topography with insights on receptor preference and immunogenicity.

Overview of attention for article published in Virology, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 1,617)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
12 news outlets
blogs
1 blog
twitter
3 tweeters
facebook
2 Facebook pages

Readers on

mendeley
26 Mendeley
citeulike
1 CiteULike
Title
Modeling of the human rhinovirus C capsid suggests a novel topography with insights on receptor preference and immunogenicity.
Published in
Virology, January 2014
DOI 10.1016/j.virol.2013.10.006
Pubmed ID
Authors

Holly A. Basta, Jean-Yves Sgro, Ann C. Palmenberg

Abstract

Features of human rhinovirus (RV)-C virions that allow them to use novel cell receptors and evade immune responses are unknown. Unlike the RV-A+B, these isolates cannot be propagated in typical culture systems or grown for structure studies. Comparative sequencing, I-TASSER, MODELLER, ROBETTA, and refined alignment techniques led to a structural approximation for C15 virions, based on the extensive, resolved RV-A+B datasets. The model predicts that all RV-C VP1 proteins are shorter by 21 residues relative to the RV-A, and 35 residues relative to the RV-B, effectively shaving the RV 5-fold plateau from the particle. There are major alterations in VP1 neutralizing epitopes and the structural determinants for ICAM-1 and LDLR receptors. The VP2 and VP3 elements are similar among all RV, but the loss of sequence "words" contributing Nim1ab has increased the apparent selective pressure among the RV-C to fix mutations elsewhere in the VP1, creating a possible compensatory epitope.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 4%
Australia 1 4%
United States 1 4%
Netherlands 1 4%
Unknown 22 85%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 35%
Student > Master 4 15%
Student > Bachelor 3 12%
Researcher 3 12%
Student > Postgraduate 2 8%
Other 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 54%
Medicine and Dentistry 6 23%
Chemistry 3 12%
Social Sciences 2 8%
Engineering 1 4%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 106. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2015.
All research outputs
#29,294
of 4,714,471 outputs
Outputs from Virology
#2
of 1,617 outputs
Outputs of similar age
#1,273
of 103,667 outputs
Outputs of similar age from Virology
#1
of 22 outputs
Altmetric has tracked 4,714,471 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,617 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,667 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.