Title |
Colonization resistance: The deconvolution of a complex trait
|
---|---|
Published in |
Journal of Biological Chemistry, April 2017
|
DOI | 10.1074/jbc.r116.752295 |
Pubmed ID | |
Authors |
Erin E Olsan, Mariana X Byndloss, Franziska Faber, Fabian Rivera-Chávez, Renée M Tsolis, Andreas J Bäumler |
Abstract |
Carbapenemase-producing Enterobacteriaceae are an emerging threat to hospitals worldwide and antibiotic exposure is a risk factor for developing fecal carriage that may lead to nosocomial infection. Here we review how antibiotics reduce colonization resistance against Enterobacteriaceae to pinpoint possible control points for curbing their spread. Recent work identifies host-derived respiratory electron acceptors as a critical resource driving a post-antibiotic expansion of Enterobacteriaceae within the large bowel. By providing a conceptual framework for colonization resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epithelial cells as a possible target for intervention strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 24% |
Australia | 2 | 8% |
Netherlands | 1 | 4% |
France | 1 | 4% |
Canada | 1 | 4% |
Chile | 1 | 4% |
United Kingdom | 1 | 4% |
Unknown | 12 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 16 | 64% |
Members of the public | 8 | 32% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 112 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 18% |
Student > Ph. D. Student | 16 | 14% |
Student > Master | 14 | 13% |
Student > Bachelor | 11 | 10% |
Student > Doctoral Student | 7 | 6% |
Other | 16 | 14% |
Unknown | 28 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 19 | 17% |
Immunology and Microbiology | 17 | 15% |
Agricultural and Biological Sciences | 16 | 14% |
Medicine and Dentistry | 11 | 10% |
Environmental Science | 3 | 3% |
Other | 11 | 10% |
Unknown | 35 | 31% |