Title |
CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection
|
---|---|
Published in |
PLoS Pathogens, April 2017
|
DOI | 10.1371/journal.ppat.1006311 |
Pubmed ID | |
Authors |
Cindy S. E. Tan, Clara Lawler, Philip G. Stevenson |
Abstract |
Gamma-herpesvirus infections are regulated by both CD4+ and CD8+ T cells. However clinical disease occurs mainly in CD4+ T cell-deficient hosts. In CD4+ T cell-deficient mice, CD8+ T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lung infections differ in distribution: most acute infection was epithelial, whereas most chronic infection was in myeloid cells. CD8+ T cells controlled epithelial infection, but CD4+ T cells and IFNγ were required to control myeloid cell infection. Disrupting the MuHV-4 K3, which degrades MHC class I heavy chains, increased viral epitope presentation by infected lung alveolar macrophages and allowed CD8+ T cells to prevent disease. Thus, viral CD8+ T cell evasion led to niche-specific immune control, and an essential role for CD4+ T cells in limiting chronic infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 14% |
France | 1 | 14% |
Spain | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 43% |
Science communicators (journalists, bloggers, editors) | 2 | 29% |
Members of the public | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 29% |
Student > Doctoral Student | 2 | 14% |
Researcher | 2 | 14% |
Student > Master | 1 | 7% |
Professor | 1 | 7% |
Other | 2 | 14% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 9 | 64% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Unknown | 3 | 21% |