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CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection

Overview of attention for article published in PLoS Pathogens, April 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

twitter
7 tweeters
f1000
1 research highlight platform

Citations

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3 Dimensions

Readers on

mendeley
8 Mendeley
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Title
CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection
Published in
PLoS Pathogens, April 2017
DOI 10.1371/journal.ppat.1006311
Pubmed ID
Authors

Cindy S. E. Tan, Clara Lawler, Philip G. Stevenson

Abstract

Gamma-herpesvirus infections are regulated by both CD4+ and CD8+ T cells. However clinical disease occurs mainly in CD4+ T cell-deficient hosts. In CD4+ T cell-deficient mice, CD8+ T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lung infections differ in distribution: most acute infection was epithelial, whereas most chronic infection was in myeloid cells. CD8+ T cells controlled epithelial infection, but CD4+ T cells and IFNγ were required to control myeloid cell infection. Disrupting the MuHV-4 K3, which degrades MHC class I heavy chains, increased viral epitope presentation by infected lung alveolar macrophages and allowed CD8+ T cells to prevent disease. Thus, viral CD8+ T cell evasion led to niche-specific immune control, and an essential role for CD4+ T cells in limiting chronic infection.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 13%
Unknown 7 88%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 25%
Professor > Associate Professor 2 25%
Student > Ph. D. Student 2 25%
Student > Postgraduate 1 13%
Student > Doctoral Student 1 13%
Other 0 0%
Readers by discipline Count As %
Immunology and Microbiology 3 38%
Agricultural and Biological Sciences 1 13%
Nursing and Health Professions 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Physics and Astronomy 1 13%
Other 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2017.
All research outputs
#3,326,693
of 12,378,687 outputs
Outputs from PLoS Pathogens
#3,340
of 5,872 outputs
Outputs of similar age
#87,643
of 267,412 outputs
Outputs of similar age from PLoS Pathogens
#124
of 172 outputs
Altmetric has tracked 12,378,687 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 5,872 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,412 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 172 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.