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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin
|
|---|---|
| Published in |
PLOS ONE, October 2013
|
| DOI | 10.1371/journal.pone.0078898 |
| Pubmed ID | |
| Authors |
Theofilos Poutahidis, Sean M. Kearney, Tatiana Levkovich, Peimin Qi, Bernard J. Varian, Jessica R. Lakritz, Yassin M. Ibrahim, Antonis Chatzigiagkos, Eric J. Alm, Susan E. Erdman |
| Abstract |
Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. Further, we find that Lactobacillus reuteri enhances wound-healing properties through up-regulation of the neuropeptide hormone oxytocin, a factor integral in social bonding and reproduction, by a vagus nerve-mediated pathway. Bacteria-triggered oxytocin serves to activate host CD4+Foxp3+CD25+ immune T regulatory cells conveying transplantable wound healing capacity to naive Rag2-deficient animals. This study determined oxytocin to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis. We also provide experimental evidence to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity. |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 31% |
| United Kingdom | 4 | 7% |
| Canada | 3 | 5% |
| China | 1 | 2% |
| Ireland | 1 | 2% |
| Mexico | 1 | 2% |
| Spain | 1 | 2% |
| Brazil | 1 | 2% |
| Bahamas | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 21 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 46 | 84% |
| Scientists | 4 | 7% |
| Practitioners (doctors, other healthcare professionals) | 4 | 7% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 381 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Hungary | 1 | <1% |
| Ireland | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 375 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 14% |
| Researcher | 52 | 14% |
| Student > Master | 51 | 13% |
| Student > Bachelor | 40 | 10% |
| Student > Doctoral Student | 24 | 6% |
| Other | 65 | 17% |
| Unknown | 96 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 71 | 19% |
| Medicine and Dentistry | 56 | 15% |
| Biochemistry, Genetics and Molecular Biology | 41 | 11% |
| Neuroscience | 26 | 7% |
| Immunology and Microbiology | 17 | 4% |
| Other | 59 | 15% |
| Unknown | 111 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 122. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2024.
All research outputs
#349,179
of 25,721,020 outputs
Outputs from PLOS ONE
#4,953
of 223,914 outputs
Outputs of similar age
#2,639
of 226,437 outputs
Outputs of similar age from PLOS ONE
#116
of 5,133 outputs
Altmetric has tracked 25,721,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223,914 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,437 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 5,133 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.