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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
|
|---|---|
| Published in |
Science, November 2013
|
| DOI | 10.1126/science.1243283 |
| Pubmed ID | |
| Authors |
Jason S. McLellan, Man Chen, M. Gordon Joyce, Mallika Sastry, Guillaume B. E. Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W. Graepel, Azad Kumar, Syed Moin, Jeffrey C. Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q. Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S. Graham, Peter D. Kwong |
| Abstract |
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5 years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable site specific to the prefusion state of the RSV fusion (F) glycoprotein, as this site is targeted by extremely potent RSV-neutralizing antibodies. Structure-based design yielded stabilized versions of RSV F that maintained antigenic site Ø when exposed to extremes of pH, osmolality, and temperature. Six RSV F crystal structures provided atomic-level data on how introduced cysteine residues and filled hydrophobic cavities improved stability. Immunization with site Ø-stabilized variants of RSV F in mice and macaques elicited levels of RSV-specific neutralizing activity many times the protective threshold. |
X Demographics
The data shown below were collected from the profiles of 74 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 11 | 15% |
| United States | 8 | 11% |
| United Kingdom | 4 | 5% |
| Comoros | 2 | 3% |
| Malaysia | 1 | 1% |
| Germany | 1 | 1% |
| Portugal | 1 | 1% |
| Austria | 1 | 1% |
| Curaçao | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 42 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 63 | 85% |
| Scientists | 8 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 562 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 1% |
| United Kingdom | 4 | <1% |
| Japan | 3 | <1% |
| Ireland | 1 | <1% |
| Israel | 1 | <1% |
| Netherlands | 1 | <1% |
| Taiwan | 1 | <1% |
| Colombia | 1 | <1% |
| Germany | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 542 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 136 | 24% |
| Researcher | 114 | 20% |
| Student > Master | 48 | 9% |
| Student > Bachelor | 39 | 7% |
| Student > Doctoral Student | 29 | 5% |
| Other | 90 | 16% |
| Unknown | 106 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 138 | 25% |
| Biochemistry, Genetics and Molecular Biology | 114 | 20% |
| Immunology and Microbiology | 64 | 11% |
| Medicine and Dentistry | 46 | 8% |
| Chemistry | 21 | 4% |
| Other | 63 | 11% |
| Unknown | 116 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 618. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2024.
All research outputs
#37,050
of 25,800,372 outputs
Outputs from Science
#1,557
of 83,305 outputs
Outputs of similar age
#196
of 227,683 outputs
Outputs of similar age from Science
#15
of 888 outputs
Altmetric has tracked 25,800,372 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,305 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,683 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 888 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.