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NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies

Overview of attention for article published in Immunity & Ageing, June 2013
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Mentioned by

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1 tweeter

Citations

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43 Dimensions

Readers on

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83 Mendeley
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Title
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
Published in
Immunity & Ageing, June 2013
DOI 10.1186/1742-4933-10-24
Pubmed ID
Authors

Carmela R Balistreri, Giuseppina Candore, Giulia Accardi, Giuseppina Colonna-Romano, Domenico Lio

Abstract

Chronic inflammation is a major biological mechanism underpinning biological ageing process and age-related diseases. Inflammation is also the key response of host defense against pathogens and tissue injury. Current opinion sustains that during evolution the host defense and ageing process have become linked together. Thus, the large array of defense factors and mechanisms linked to the NF-κB system seem to be involved in ageing process. This concept leads us in proposing inductors of NF-κB signaling pathway as potential ageing biomarkers. On the other hand, ageing biomarkers, represented by biological indicators and selected through apposite criteria, should help to characterize biological age and, since age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. In this report, some inflammatory biomarkers will be discussed for a better understanding of the concept of biological ageing, providing ideas on eventual working hypothesis about potential targets for the development of new therapeutic strategies and improving, as consequence, the quality of life of elderly population.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 1%
United Kingdom 1 1%
Canada 1 1%
Iran, Islamic Republic of 1 1%
United States 1 1%
Unknown 78 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 24%
Student > Ph. D. Student 17 20%
Student > Master 10 12%
Student > Bachelor 6 7%
Student > Doctoral Student 5 6%
Other 16 19%
Unknown 9 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 39%
Medicine and Dentistry 14 17%
Biochemistry, Genetics and Molecular Biology 13 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Chemistry 3 4%
Other 7 8%
Unknown 11 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2013.
All research outputs
#2,302,840
of 4,507,509 outputs
Outputs from Immunity & Ageing
#43
of 83 outputs
Outputs of similar age
#50,790
of 102,626 outputs
Outputs of similar age from Immunity & Ageing
#1
of 2 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 83 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,626 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them