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Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

Overview of attention for article published in PLOS ONE, November 2013
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Title
Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
Published in
PLOS ONE, November 2013
DOI 10.1371/journal.pone.0080669
Pubmed ID
Authors

Andrés Obregón-Henao, Marcela Henao-Tamayo, Ian M. Orme, Diane J. Ordway

Abstract

Tuberculosis is one of the world's leading killers, stealing 1.4 million lives and causing 8.7 million new and relapsed infections in 2011. The only vaccine against tuberculosis is BCG which demonstrates variable efficacy in adults worldwide. Human infection with Mycobacterium tuberculosis results in the influx of inflammatory cells to the lung in an attempt to wall off bacilli by forming a granuloma. Gr1(int)CD11b(+) cells are called myeloid-derived suppressor cells (MDSC) and play a major role in regulation of inflammation in many pathological conditions. Although MDSC have been described primarily in cancer their function in tuberculosis remains unknown. During M. tuberculosis infection it is crucial to understand the function of cells involved in the regulation of inflammation during granuloma formation. Understanding their relative impact on the bacilli and other cellular phenotypes is necessary for future vaccine and drug design.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 29%
Student > Ph. D. Student 14 18%
Student > Master 10 13%
Student > Bachelor 4 5%
Other 4 5%
Other 14 18%
Unknown 9 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 32%
Immunology and Microbiology 17 22%
Medicine and Dentistry 10 13%
Biochemistry, Genetics and Molecular Biology 7 9%
Unspecified 2 3%
Other 5 6%
Unknown 12 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2013.
All research outputs
#20,209,145
of 22,729,647 outputs
Outputs from PLOS ONE
#173,132
of 194,027 outputs
Outputs of similar age
#186,090
of 213,637 outputs
Outputs of similar age from PLOS ONE
#4,423
of 5,128 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,027 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,637 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,128 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.