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Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

Overview of attention for article published in Journal of Translational Medicine, November 2013
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2 tweeters

Citations

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125 Dimensions

Readers on

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162 Mendeley
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Title
Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells
Published in
Journal of Translational Medicine, November 2013
DOI 10.1186/1479-5876-11-280
Pubmed ID
Authors

Birdal Bilir, Omer Kucuk, Carlos S Moreno

Abstract

Triple-negative breast cancer (TNBC) is an aggressive clinical subtype of breast cancer that is characterized by the lack of estrogen receptor (ER) and progesterone receptor (PR) expression as well as human epidermal growth factor receptor 2 (HER2) overexpression. The TNBC subtype constitutes approximately 10%-20% of all breast cancers, but has no effective molecular targeted therapies. Previous meta-analysis of gene expression profiles of 587 TNBC cases from 21 studies demonstrated high expression of Wnt signaling pathway-associated genes in basal-like 2 and mesenchymal subtypes of TNBC. In this study, we investigated the potential of Wnt pathway inhibitors in effective treatment of TNBC.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Netherlands 1 <1%
India 1 <1%
Turkey 1 <1%
Unknown 156 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 44 27%
Researcher 27 17%
Student > Master 19 12%
Student > Bachelor 19 12%
Student > Doctoral Student 14 9%
Other 17 10%
Unknown 22 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 30%
Biochemistry, Genetics and Molecular Biology 40 25%
Medicine and Dentistry 27 17%
Engineering 5 3%
Chemistry 3 2%
Other 14 9%
Unknown 25 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2013.
All research outputs
#17,257,972
of 21,352,585 outputs
Outputs from Journal of Translational Medicine
#2,828
of 3,682 outputs
Outputs of similar age
#156,133
of 211,345 outputs
Outputs of similar age from Journal of Translational Medicine
#144
of 197 outputs
Altmetric has tracked 21,352,585 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,682 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,345 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 197 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.