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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alzheimer’s Disease: Analyzing the Missing Heritability
|
|---|---|
| Published in |
PLOS ONE, November 2013
|
| DOI | 10.1371/journal.pone.0079771 |
| Pubmed ID | |
| Authors |
Perry G. Ridge, Shubhabrata Mukherjee, Paul K. Crane, John S. K. Kauwe, Alzheimer’s Disease Genetics Consortium |
| Abstract |
Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide Complex Trait Analysis to analyze >2 million SNPs for 10,922 individuals from the Alzheimer's Disease Genetics Consortium to assess the phenotypic variance explained first by known late-onset AD loci, and then by all SNPs in the Alzheimer's Disease Genetics Consortium dataset. In all, 33% of total phenotypic variance is explained by all common SNPs. APOE alone explained 6% and other known markers 2%, meaning more than 25% of phenotypic variance remains unexplained by known markers, but is tagged by common SNPs included on genotyping arrays or imputed with HapMap genotypes. Novel AD markers that explain large amounts of phenotypic variance are likely to be rare and unidentifiable using genome-wide association studies. Based on our findings and the current direction of human genetics research, we suggest specific study designs for future studies to identify the remaining heritability of Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| Spain | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 338 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Colombia | 1 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 330 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 61 | 18% |
| Student > Ph. D. Student | 56 | 17% |
| Student > Bachelor | 40 | 12% |
| Student > Master | 36 | 11% |
| Other | 21 | 6% |
| Other | 49 | 14% |
| Unknown | 75 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 16% |
| Biochemistry, Genetics and Molecular Biology | 46 | 14% |
| Neuroscience | 40 | 12% |
| Medicine and Dentistry | 38 | 11% |
| Psychology | 15 | 4% |
| Other | 52 | 15% |
| Unknown | 94 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#1,848,947
of 22,729,647 outputs
Outputs from PLOS ONE
#23,829
of 194,027 outputs
Outputs of similar age
#18,599
of 215,614 outputs
Outputs of similar age from PLOS ONE
#663
of 5,222 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 194,027 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 5,222 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.