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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis
|
|---|---|
| Published in |
Journal of Molecular Psychiatry, November 2013
|
| DOI | 10.1186/2049-9256-1-19 |
| Pubmed ID | |
| Authors |
Melkaye G Melka, Christina A Castellani, Benjamin I Laufer, N Rajakumar, Richard O’Reilly, Shiva M Singh |
| Abstract |
The dopamine (DA) hypothesis of schizophrenia proposes the mental illness is caused by excessive transmission of dopamine in selected brain regions. Multiple lines of evidence, including blockage of dopamine receptors by antipsychotic drugs that are used to treat schizophrenia, support the hypothesis. However, the dopamine D2 receptor (DRD2) blockade cannot explain some important aspects of the therapeutic effect of antipsychotic drugs. In this study, we hypothesized that antipsychotic drugs could affect the transcription of genes in the DA pathway by altering their epigenetic profile. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 21% |
| Student > Bachelor | 8 | 15% |
| Student > Master | 7 | 13% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Postgraduate | 5 | 9% |
| Other | 9 | 17% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 30% |
| Biochemistry, Genetics and Molecular Biology | 12 | 23% |
| Neuroscience | 6 | 11% |
| Medicine and Dentistry | 5 | 9% |
| Psychology | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 8 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2015.
All research outputs
#14,765,501
of 22,729,647 outputs
Outputs from Journal of Molecular Psychiatry
#24
of 32 outputs
Outputs of similar age
#127,072
of 214,634 outputs
Outputs of similar age from Journal of Molecular Psychiatry
#2
of 2 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one scored the same or higher as 8 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,634 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.