Title |
Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds
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Published in |
BMC Genomics, November 2013
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DOI | 10.1186/1471-2164-14-784 |
Pubmed ID | |
Authors |
Katie E Fowler, Ricardo Pong-Wong, Julien Bauer, Emily J Clemente, Christopher P Reitter, Nabeel A Affara, Stephen Waite, Grant A Walling, Darren K Griffin |
Abstract |
Obesity, excess fat tissue in the body, can underlie a variety of medical complaints including heart disease, stroke and cancer. The pig is an excellent model organism for the study of various human disorders, including obesity, as well as being the foremost agricultural species. In order to identify genetic variants associated with fatness, we used a selective genomic approach sampling DNA from animals at the extreme ends of the fat and lean spectrum using estimated breeding values derived from a total population size of over 70,000 animals. DNA from 3 breeds (Sire Line Large White, Duroc and a white Pietrain composite line (Titan)) was used to interrogate the Illumina Porcine SNP60 Genotyping Beadchip in order to identify significant associations in terms of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). |
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Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 18% |
Student > Ph. D. Student | 8 | 13% |
Student > Bachelor | 8 | 13% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 5 | 8% |
Other | 9 | 15% |
Unknown | 15 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Medicine and Dentistry | 4 | 6% |
Engineering | 2 | 3% |
Nursing and Health Professions | 2 | 3% |
Other | 4 | 6% |
Unknown | 21 | 34% |