↓ Skip to main content

Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death

Overview of attention for article published in International Journal of Nanomedicine, August 2013
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
41 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death
Published in
International Journal of Nanomedicine, August 2013
DOI 10.2147/ijn.s40766
Pubmed ID
Authors

Akiko Sato, Naoki Itcho, Hitoshi Ishiguro, Daiki Okamoto, Naohito Kobayashi, Kazuaki Kawai, Hiroshi Kasai, Daisuke Kurioka, Hiroji Uemura, Yoshinobu Kubota, Masatoshi Watanabe

Abstract

Docetaxel (DTX) is one of the most important anticancer drugs; however, the severity of its adverse effects detracts from its practical use in the clinic. Magnetic nanoparticles of Fe3O4 (MgNPs-Fe3O4) can enhance the delivery and efficacy of anticancer drugs. We investigated the effects of MgNPs-Fe3O4 or DTX alone, and in combination with prostate cancer cell growth in vitro, as well as with the mechanism underlying the cytotoxic effects. MgNPs-Fe3O4 caused dose-dependent increases in reactive oxygen species levels in DU145, PC-3, and LNCaP cells; 8-hydroxydeoxyguanosine levels were also elevated. MgNPs-Fe3O4 alone reduced the viability of LNCaP and PC-3 cells; however, MgNPs-Fe3O4 enhanced the cytotoxic effect of a low dose of DTX in all three cell lines. MgNPs-Fe3O4 also augmented the percentage of DU145 cells undergoing apoptosis following treatment with low dose DTX. Expression of nuclear transcription factor κB in DU145 was not affected by MgNPs-Fe3O4 or DTX alone; however, combined treatment suppressed nuclear transcription factor κB expression. These findings offer the possibility that MgNPs-Fe3O4-low dose DTX combination therapy may be effective in treating prostate cancer with limited adverse effects.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 29%
Student > Bachelor 7 17%
Researcher 5 12%
Student > Master 4 10%
Student > Doctoral Student 1 2%
Other 5 12%
Unknown 7 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 20%
Medicine and Dentistry 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Engineering 4 10%
Chemistry 3 7%
Other 9 22%
Unknown 8 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2013.
All research outputs
#20,823,121
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#3,113
of 4,077 outputs
Outputs of similar age
#160,283
of 210,451 outputs
Outputs of similar age from International Journal of Nanomedicine
#97
of 101 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,077 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,451 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.