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Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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Title
Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20175742
Pubmed ID
Authors

C.F.S.M.P. Silveira, D.H.S. Campos, P.P. Freire, A.F. Deus, K. Okoshi, C.R. Padovani, A.C. Cicogna

Abstract

Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a known factor that influences function. A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). Our hypothesis was that SERCA2a participates in such dysfunction. Thirty-day-old male Wistar rats (60-80 g) were divided into AoS and Sham groups, which were submitted to surgery with or without aorta clipping, respectively. After 6 weeks, the animals were submitted to echocardiogram and functional analysis by isolated papillary muscle (IPM) in basal condition, hypoxia, and SERCA2a blockage with cyclopiazonic acid at calcium concentrations of 0.5, 1.5, and 2.5 mM. Western-blot analyses were used for SERCA2a and phospholamban detection. Data analysis was carried out with Student's t-test and ANOVA. AoS enhanced left atrium and E and A wave ratio, with preserved ejection fraction. Basal condition in IPM showed similar increases in developed tension (DT) and resting tension (RT) in AoS, and hypoxia was similar between groups. After cyclopiazonic acid blockage, final DT was equally decreased and RT was similar between groups, but the speed of relaxation was decreased in the AoS group. Western-blot was uniform in all evaluations. The hypothesis was confirmed, since functional parameters regarding SERCA2a were changed in the AoS group.

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Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 25%
Researcher 5 21%
Student > Master 4 17%
Student > Postgraduate 3 13%
Student > Ph. D. Student 1 4%
Other 3 13%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 10 42%
Nursing and Health Professions 4 17%
Biochemistry, Genetics and Molecular Biology 3 13%
Business, Management and Accounting 1 4%
Psychology 1 4%
Other 3 13%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2017.
All research outputs
#19,069,905
of 21,431,229 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#528
of 580 outputs
Outputs of similar age
#245,420
of 283,745 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#2
of 8 outputs
Altmetric has tracked 21,431,229 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 580 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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