Title |
RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006
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Published in |
BMC Genomics, November 2013
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DOI | 10.1186/1471-2164-14-822 |
Pubmed ID | |
Authors |
Nabil M Wilf, Adam J Reid, Joshua P Ramsay, Neil R Williamson, Nicholas J Croucher, Laurent Gatto, Svenja S Hester, David Goulding, Lars Barquist, Kathryn S Lilley, Robert A Kingsley, Gordon Dougan, George PC Salmond |
Abstract |
Serratia sp. ATCC 39006 (S39006) is a Gram-negative enterobacterium that is virulent in plant and animal models. It produces a red-pigmented trypyrrole secondary metabolite, prodigiosin (Pig), and a carbapenem antibiotic (Car), as well as the exoenzymes, pectate lyase and cellulase. Secondary metabolite production in this strain is controlled by a complex regulatory network involving quorum sensing (QS). Hfq and RsmA (two RNA binding proteins and major post-transcriptional regulators of gene expression) play opposing roles in the regulation of several key phenotypes within S39006. Prodigiosin and carbapenem production was abolished, and virulence attenuated, in an S39006 ∆hfq mutant, while the converse was observed in an S39006 rsmA transposon insertion mutant. |
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