Title |
Differentiation of irradiation and cetuximab induced skin reactions in patients with locally advanced head and neck cancer undergoing radioimmunotherapy: the HICARE protocol (Head and neck cancer: ImmunoChemo and Radiotherapy with Erbitux) – a multicenter phase IV trial
|
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Published in |
BMC Cancer, July 2013
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DOI | 10.1186/1471-2407-13-345 |
Pubmed ID | |
Authors |
G Habl, K Potthoff, MF Haefner, A Abdollahi, JC Hassel, E Boller, M Indorf, J Debus |
Abstract |
In order to improve the clinical outcome of patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN) not being capable to receive platinum-based chemoradiation, radiotherapy can be intensified by addition of cetuximab, a monoclonal antibody that blocks the epidermal growth factor receptor (EGFR). The radioimmunotherapy with cetuximab is a feasible treatment option showing a favourable toxicity profile. The most frequent side effect of radiotherapy is radiation dermatitis, the most common side effect of treatment with cetuximab is acneiform rash. Incidence and severity of these frequent, often overlapping and sometimes limiting skin reactions, however, are not well explored. A clinical and molecular differentiation between radiogenic skin reactions and skin reactions caused by cetuximab which may correlate with outcome, have never been described before. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 3 | 7% |
France | 1 | 2% |
Unknown | 41 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 20% |
Student > Master | 7 | 16% |
Student > Ph. D. Student | 5 | 11% |
Other | 4 | 9% |
Professor > Associate Professor | 3 | 7% |
Other | 9 | 20% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 42% |
Nursing and Health Professions | 5 | 11% |
Agricultural and Biological Sciences | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Psychology | 2 | 4% |
Other | 6 | 13% |
Unknown | 8 | 18% |