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Obese Locus in WNIN/Obese Rat Maps on Chromosome 5 Upstream of Leptin Receptor

Overview of attention for article published in PLOS ONE, October 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

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1 Facebook page
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4 Wikipedia pages

Citations

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20 Dimensions

Readers on

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13 Mendeley
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Title
Obese Locus in WNIN/Obese Rat Maps on Chromosome 5 Upstream of Leptin Receptor
Published in
PLOS ONE, October 2013
DOI 10.1371/journal.pone.0077679
Pubmed ID
Authors

Rajender Rao Kalashikam, Kiran Kumar Battula, Veerababu Kirlampalli, Jeffrey M. Friedman, Giridharan Nappanveettil

Abstract

WNIN/Obese (WNIN/Ob) rat a new mutant model of metabolic syndrome was identified in 1996 from an inbred Wistar rat strain, WNIN. So far several papers are published on this model highlighting its physical, biochemical and metabolic traits. WNIN/Ob is leptin resistant with unaltered leptin or its receptor coding sequences--the two well-known candidate genes for obesity. Genotyping analysis of F2 progeny (raised from WNIN/Ob × Fisher--344) in the present study localized the mutation to a recombinant region of 14.15cM on chromosome 5. This was further corroborated by QTL analysis for body weight, which narrowed this region to 4.43 cM with flanking markers D5Rat256 & D5Wox37. Interval mapping of body weight QTL shows that the LOD score peak maps upstream of leptin receptor and shows an additive effect suggesting this as a novel mutation and signifying the model as a valuable resource for studies on obesity and metabolic syndrome.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 31%
Student > Bachelor 3 23%
Lecturer 1 8%
Student > Ph. D. Student 1 8%
Student > Doctoral Student 1 8%
Other 2 15%
Unknown 1 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 38%
Biochemistry, Genetics and Molecular Biology 3 23%
Medicine and Dentistry 2 15%
Neuroscience 1 8%
Social Sciences 1 8%
Other 0 0%
Unknown 1 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2022.
All research outputs
#7,444,902
of 23,408,972 outputs
Outputs from PLOS ONE
#90,851
of 200,329 outputs
Outputs of similar age
#68,820
of 213,228 outputs
Outputs of similar age from PLOS ONE
#2,011
of 5,167 outputs
Altmetric has tracked 23,408,972 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 200,329 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,228 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 5,167 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.