Title |
Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans
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Published in |
Cardiovascular Diabetology, August 2013
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DOI | 10.1186/1475-2840-12-117 |
Pubmed ID | |
Authors |
Katja Piotrowski, Melanie Becker, Julia Zugwurst, Ingeborg Biller-Friedmann, Gerald Spoettl, Martin Greif, Alexander W Leber, Alexander Becker, Rüdiger P Laubender, Corinna Lebherz, Burkhard Goeke, Nikolaus Marx, Klaus G Parhofer, Michael Lehrke |
Abstract |
GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for GLP-1 in experimental models. Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 14% |
Student > Master | 9 | 14% |
Student > Ph. D. Student | 7 | 11% |
Student > Postgraduate | 7 | 11% |
Student > Bachelor | 4 | 6% |
Other | 13 | 20% |
Unknown | 17 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 32 | 48% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Agricultural and Biological Sciences | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Immunology and Microbiology | 1 | 2% |
Other | 2 | 3% |
Unknown | 21 | 32% |